منابع مشابه
Astrocytes in the Epileptic Brain
The roles that astrocytes play in the evolution of abnormal network excitability in chronic neurological disorders involving brain injury, such as acquired epilepsy, are receiving renewed attention due to improved understanding of the molecular events underpinning the physiological functions of astrocytes. In epileptic tissue, evidence is pointing to enhanced chemical signaling and disrupted li...
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Astrocytes are key active elements of the brain that contribute to information processing. They not only provide neurons with metabolic and structural support, but also regulate neurogenesis and brain wiring. Furthermore, astrocytes modulate synaptic activity and plasticity in part by controlling the extracellular space volume, as well as ion and neurotransmitter homeostasis. These findings, to...
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Brain metastasis, the secondary growth of malignant cells within the central nervous system (CNS), exceeds the incidence of primary brain tumors (i.e., gliomas) by tenfold and are seemingly on the rise owing to the emergence of novel targeted therapies that are more effective in controlling extracranial disease relatively to intracranial lesions. Despite the fact that metastasis to the brain po...
متن کاملIn vitro aging reduces the morphological plasticity of astrocytes
Abstract Astrocytes are involved in many functions of the brain including water transport and moderation of neuronal synapses, and most functions require the astrocyte endfeet to be highly mobile. In the aging brain the functions in the brain start to deteriorate, decay or loss of metabolic functions may eventually cause diseases such as Parkinsons’s and Alzheimer’s disease. In this study cAMP-...
متن کاملNeurogenesis in the aging brain
Neurogenesis, or the birth of new neural cells, was thought to occur only in the developing nervous system and a fixed neuronal population in the adult brain was believed to be necessary to maintain the functional stability of adult brain circuitry. However, recent studies have demonstrated that neurogenesis does indeed continue into and throughout adult life in discrete regions of the central ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2001
ISSN: 0360-4012,1097-4547
DOI: 10.1002/jnr.10121